NT-proBNP is a biologically inactive peptide, so it is not cleared by NPR-C (natriuretic peptide clearance receptor-C) of adipocytes, and the decreased release can play an important role in lowering the NT-proBNP levels in obesity [1, 12, 16, 22]. The gene discussed is NPR3; the disease is obesity due to melanocortin 4 receptor deficiency.