Obesity, which is one of the disorders commonly seen in patients with heart failure, affects the NT-proBNP values in the diagnosis of heart failure [2, 3, 10–17] so significantly that many studies have suggested that the NT-proBNP level should be adjusted for the patient’s body mass index (BMI) to help diagnose heart failure more accurately [15, 18, 19]. The gene discussed is NPPB; the disease is heart failure.