ADAMTS12 and neoplasm: ADAMTS12 has been confirmed to be expressed in a variety of human tissues [6] and plays a significant role in the pathological process of various diseases, such as tumor [8], inflammation [9, 10], arthritis [11, 12], intervertebral disc degeneration [13], angiogenesis [14], schizophrenia [15], and gonadal development [16].