Surprisingly, RORα was unchanged in both the high-sugar fed and high-fat mice, which is similar to other reports in rats fed a high-sucrose diet (114), however these data are in contrast to the observations in human liver biopsies taken from patients with NAFLD and nonalcoholic steatohepatitis (NASH) (115–117). This evidence concerns the gene RORA and metabolic dysfunction-associated steatohepatitis.