Corroborating with previous studies,15, 19, 23Bsep−/− mice had generally elevated serum levels of markers of hepatocellular damage (ALT, AST) and cholestasis (AP, BAs), but this was not worsened after the infection contrary to the tendential increase of ALT and AST in infected WT mice (Figure 1D). The gene discussed is GPT; the disease is cholestasis.