On the contrary, the Mac‐2+ area, indicating the presence of inflammatory leukocytes (especially macrophages) mainly within the periovular granuloma, was reduced in Bsep−/− mice, which also harboured less F4/80+ CD206+ cells (M2 macrophages) after infection with 25 cercariae (Figure 3D). The gene discussed is MRC1; the disease is infection.