Liu et al. (2016) found that mir-203a expression increased when using 5-aza-2′-deoxycytidine to treat esophageal cancer cells. The association between 5-Fluorouracil (5-FU) and let-7c ranked the tenth according to predicted scores. Peng et al. (2015)found that overexpression of let-7c reduce Akt2 expression and under expression of Akt2 can enhance the sensitivity of renal cell to 5-Fluorouracil. Here, AKT2 is linked to esophageal cancer.