However, when we examined the expression levels of IL‐8, CXCL1, CXCL2 and CXCL3 individually by RT‐qPCR using samples from four independent shRNA knockdown trials, expression patterns of these genes did not appear to correspond with the extent of RUNX3 suppression nor tumor growth attenuation (Figure S7 and Figure 3A−C). This evidence concerns the gene RUNX3 and neoplasm.