RUNX3 and neoplasm: To gain an insight into the molecular mechanism underlying how the decreased RUNX3 expression attenuated tumor‐promoting ability of exp‐CAF 544 cells, we performed RNA‐seq and investigated differentially expressed genes between two groups: 544‐shCtrl and ‐shGFP (544 cells expressing shGFP) and 544‐shRX3‐4 and ‐shRX3‐5, the latter of which significantly reduced the tumor weight (Figure 5A).