Then, we looked into the above 60 genes (Figure 5B) with the following criteria: the gene expression is significantly increased with Log2FC >2 in 544 cells (high RUNX3 expression) compared to 522 cells (no RUNX3 expression) and is downregulated in 544 cells upon RUNX3 knockdown as it resulted in decreased tumor growth promotion in vivo (Figure 3E). This evidence concerns the gene RUNX3 and neoplasm.