NUMA1 and urinary bladder cancer: Some proteins in urine such as NMP22, Complement factor H-related protein, BLCA-4, and apolipoproteins [26] as well as various metabolites such as taurine, citrate, succinate [27, 28], desaminotyrosine, erythritol, d-ribose, ribitol, d-fructose, d-mannose, and d-galactose [29] have been found to be biomarkers for the early diagnosis of bladder cancer, and circulating MicroRNA have also been found to be used for the early diagnosis of bladder cancer [30].