IFNG and type 1 diabetes mellitus: In response to IFN-γ produced by Teff cells, antigen-specific ICOS+ Treg cells preferentially express CXCR3 in PLNs and are chemoattracted by CXCL9, CXCL10, and CXCL11 derived from intra-pancreatic APC populations and β cells, serving as a homeostatic mechanism to slow down T1D progression [117].