The study reported a notable association between placental alkaline phosphatase (PLAP), ALG-2-interacting protein X (ALIX), the CTA New York Esophageal Squamous Cell Carcinoma-1(NY-ESO-1), and EGFR, with a decreased overall survival rate emphasizing the potential advantages of utilizing exosomal membrane-bound proteins as robust prognostic biomarkers in NSCLC [66]. Here, ALPP is linked to esophageal squamous cell carcinoma.