Individuals in the fourth and fifth quintile of serum Klotho respectively had adjusted odds ratios (OR) of 0.77 (95%CI: 0.65, 0.93) and 0.67 (95%CI: 0.65, 0.93) for hyperlipidemia, with a significant linear trend (Ptrend < 0.001). The gene discussed is KL; the disease is hyperlipidemia.