Studies have shown that GLP could inhibit obesity, hyperlipidemia, inflammation, and fat accumulation in C57BL/6 J mice induced by high fat diet (HFD), and the mechanism is related to the up-regulation of toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/noncanonical nuclear factor-κB (NF-κB) signaling pathway [90]. Here, TLR4 is linked to obesity due to melanocortin 4 receptor deficiency.