In another study, G. lucidum spore powder maigh inhibit the proliferation, migration, and invasion of ESCC cells via phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of Rapamycin (mTOR) and extracellular signal-regulated kinase (ERK) pathway [96]. The gene discussed is AKT1; the disease is esophageal squamous cell carcinoma.