The Cancer Genome Atlas (TCGA) (https://portal.gdc.cancer.gov) data showed that FOXO1 was downregulated in luminal A, luminal B, HER2, and basal-like breast cancers (Fig. 2b), and positively correlated with CYP1B1-AS1 expression (R = 0.46, Fig. 2c). This evidence concerns the gene FOXO1 and breast carcinoma.