CGI-58 is key to lipid homeostasis, causing, if perturbed, Chanarin–Dorfman syndrome in humans and LD overaccumulation in Arabidopsis69,70 (Fig. 5c); CGI-58 is the 22nd most connected gene in Arabidopsis module 5 (Fig. 5h). This evidence concerns the gene ABHD5 and Dorfman-Chanarin disease.