RBFOX2 and chronic myelogenous leukemia, BCR-ABL1 positive: While investigating the role of RBFOX2 in K562 (a chronic myelogenous leukaemia cell line) cells, we found that RBFOX2 depletion led to a noticeably reduced colony forming ability and impaired cell growth (Fig. 4a,b and Extended Data Fig. 5a).