To investigate whether this TGF-β signalling pathway regulation mediated through RBFOX2 also occurs in human AML cells, we first confirmed that RBFOX2 KD caused a decrease in m6A level, an increase in paRNA abundance and a reduction in PRC2 binding at the promoter region of TGFB1 (Extended Data Fig. 10h–j). The gene discussed is TGFB1; the disease is acute myeloid leukemia.