Moreover, Keap1 works as a E3 ligase of IKKβ, since it has an ETGE-Motif-NQE36TGE39- homologous to the one present in the Nrf2 protein, so KEAP1 is considered as a IKKβ interacting protein [17] and mutations or alterations in Keap1 gene are correlated with cancer or a deeply altered cell stress response [18]. Here, IKBKB is linked to cancer.