For green module (1677 genes), the enriched pathway included Prostate cancer, MAPK signaling pathway, Estrogen signaling pathway, Choline metabolism in cancer, Prolactin signaling pathway, Insulin signaling pathway, Renal cell carcinoma and Cortisol synthesis and secretion, all of which are related to ACTH and DHEA function. Here, POMC is linked to hereditary clear cell renal cell carcinoma.