KISS1R and Interstitial cardiac fibrosis: In fact, Zhang et al. reported that the KISS1R agonist KP-10 (sc. 40 nmol KP-10 dissolved in 200 μL saline for 7 days) led to cardiac interstitial fibrosis and altered the morphology and structure of myocardial cells, serum metabolite levels, and expression of genes and proteins in the heart tissue obtained from healthy male Sprague–Dawley rats25.