Previous study found that LAMP1 spots increased in Mucopolysaccharidosis (MPS) III cells, a severe inborn metabolic error caused by mutations of the sulfamidase gene (SGSH), a lysosomal enzyme that participates in the metabolism of the glycosaminoglycan (GAG), heparan sulfate (HS), associated with neurodegeneration and dementia25. This evidence concerns the gene SGSH and mucopolysaccharidosis type 3A.