In the study of insulin resistance, activating ERS could inhibit autophagy flux through IRE1 signal pathway, leading to insulin resistance25.ERS inhibits autophagy flux by IRE1signaling pathway, leading to the accumulation of mutant huntingtin protein aggregates and neurotoxicity in Huntingtin26.IRE1 interferes with autophagic flux mainly through the following ways: 1. This evidence concerns the gene HTT and Insulin resistance.