Matsusaka et al. indicated that AGP activates intracellular STAT1 by binding to CD14, a co-receptor for toll-like receptor 4 (TLR4) on macrophages, thereby inducing programmed death ligand 1 (PD-L1) expression and producing IL-6, which in turn promotes tumor progression37. The gene discussed is TLR4; the disease is neoplasm.