To address these questions, we studied an independent set of 22 AD brains (Braak 5/6, Medial Temporal Gyrus, Table S4) and conducted multiplexed proteomics with imaging mass cytometry (IMC) to co-localise TSPO expression with markers of microglial phenotype, amyloid and tau (Fig. 4a). The gene discussed is MAPT; the disease is Alzheimer disease.