SMPD3 and acute myeloid leukemia: This apparent “translocation” of nSMase2 happened as early as 6 h following PAL treatment (Fig. 3B) and was similarly seen in primary mouse hepatocytes (Fig. 3C) and in AML-12 cells, a normal, mouse-derived hepatic cell line (Fig. 3D) (See supplemental Fig. S3 for pictures taken at lower magnification).