Another study in the WHI Observational Study cohort (including 821 incident CRC case-control matched pairs) that focused on 30 FOCM genes found significant interactions for variants in DNA methyltransferase 3 alpha (DNMT3A) (locus 2p23.3) with plasma folate, and DNMT1 (locus 19p13.2) with red blood cell folate (false discovery rate adjusted q-value was 0.02 for both interaction loci) [23]. This evidence concerns the gene DNMT1 and colorectal carcinoma.