APC and osteoporosis: MiR-135b affects many molecular biological pathways, including homeostasis, osteoporosis, neurological diseases, CRC, and gastric cancer.16, 17, 18, 19 In CRC, miRNA-135b can target the 3’-UTR of Adenomatous Polyposis Coli (APC) and restrain its expression, resulting in the aberrant activation of the Wnt signaling pathway.16