EGFR and colorectal carcinoma: Activation of the Epidermal Growth Factor Receptor (EGFR) pathway triggers several downstream signaling pathways, including the RAS/RAF/MEK/Extracellular Signal-Related Kinase (ERK)/Phosphatidylinositol 3-Kinases (PI3K)/AKT, and JAK/STAT3 pathways, to regulate cell growth, survival, and migration in CRC.