Men with CVD had lower testosterone (-0.35 nmol/L, CI=-0.55,-0.15) with no difference in SHBG or other hormones, while COPD was not associated with any hormones (Table 1, Fig. 2j,l, Supplementary Figs. S5-S8j,l). The gene discussed is SHBG; the disease is chronic obstructive pulmonary disease.