MALAT1 and Familial prostate cancer: Among these miRNAs, miR-141-3p was selected for the following investigation because it was recently documented to directly target ALKBH5 expression and involve in prostate cancer progression (Figure 3d).26 As a result, silencing MALAT1 increased miR-141-3p expression, while miR-141-3p mimics downregulated the mRNA expression level of ALKBH5 (Figure 3e–g).