RBX1 and cancer: Moreover, RBX1 was reported to be essential for cancer cell proliferation and survival.10–12 Upon13,14 RBX1 siRNA silencing, cancer cells sequentially undergo cell cycle arrest, senescence and apoptosis.12 Tan M et al reported that mouse Rbx1 loss caused early embryonic lethality owing to the significant accumulation of p27, which suppressed proliferation.10 Although RBX1 is the key component of SCF E3 ligase, the physiological function of RBX1 in p27 accumulation and its correlation with cell cycle arrest and resistance to chemotherapeutic drugs in MM cells remains uncharacterized.