SLC2A4 and Hyperglycemia: The GLUT4 trafficking data (Figure 3, A–C) together with improved blood glucose tolerance (Figure 1G) with reduced hyperglycemia (Figure 1E) following cBIN1 treatment in db/db mice, and ability of cardiomyocytes to take up glucose (Figure 3D), collectively point to a possibility of direct cardiomyocyte contribution to blood glucose regulation in patients with T2DM.