Another significant CNV (CNV3942) associated with the LSS gene that encodes lanosterol synthase enzyme which converts (S)-2,3-oxidosqualene to lanosterol in the cholesterol biosynthesis pathway and which has the crucial function of the metabolic pathway in the homeostasis of hair growth and disruption of expression level caused congenital cataracts and skin lesions. The gene discussed is LSS; the disease is early-onset non-syndromic cataract.