Tau fibrilsfrom AD are comprised of mixed 3/4-repeat (3/4R) microtube bindingdomains, while only 4-repeat tau (4R tau) aggregates are identifiedin CBD and PSP.12−16 Additionally, these fibrils are distributed in different sites/regionsin the AD/CBD/PSP brains, and the distributions are also related tothe progress of dementia.17 This evidence concerns the gene MAPT and Alzheimer disease.