IFNA1 and infection: While initially contradictory, it must be noted that ADE-mediated suppression of type I interferon production was only observed at a narrow range of serum dilutions corresponding to the peak infection enhancement in this model, and that most other DENV-immune serum dilutions (including many that enhanced DENV infection) resulted in similar or significantly elevated rates of IFN production relative to DENV-infection alone [37].