To determine whether the secretory neutrophil subsets induced by OTUD1 depletion is similar to Neu1 from patients with periodontitis, we analyzed the status of genes altered in neutrophil subsets and found that the Neu1 subset in mice exhibited similar characteristics to those of the secretory neutrophil subset in Neu 1 from patients with periodontitis (Figure S5D,E, Supporting Information). This evidence concerns the gene NEU1 and periodontitis.