While OTUD1 is known to be ubiquitously expressed in multiple tissues, the biological functions of OTUD1 are manifested in a context‐dependent manner, depending on the specific tissue, organ or pathological condition.[14] To determine whether loss of OTUD1 in immune cells or non‐immune cells contributes to severe periodontitis, we generated bone marrow chimeric mice via adoptive transfer of bone marrow. The gene discussed is OTUD1; the disease is periodontitis.