Trafficking of transmembrane and secretory proteins from the ER to Golgi apparatus is mediated by COPII vesicle, which is composed of secretion associated Ras related GTPase 1 (SAR1), SEC23‐SEC24 heterodimeric complex, and SEC13‐SEC31 heterodimeric complex.[27, 28] Emerging evidence have now shown that dysregulation of COPII components is associated with host immune disorders. Here, SEC24B is linked to immune system disorder.