Four RCTs compared TAT (with Vit K antagonist) versus DAT (with a P2Y12 inhibitor, mainly clopidogrel) plus multiple adjusted doses of NOACs, rivaroxaban 15 mg o.d. (PIONEER AF-PCI), dabigatran 110 mg or 150 mg b.i.d. (RE-DUAL PCI), apixaban 5 mg b.i.d. (AUGUSTUS), and edoxaban 60 mg o.d. (ENTRUST-AF PCI) in AF patients undergoing PCI (see the summary of these trials in Table 2). The gene discussed is P2RY12; the disease is atrial fibrillation.