Treatment of MM cells with C6-ceramide (ExoC6-cer), used to mimic the endogenous effects of ceramide, led to the inhibition of MM cell proliferation [125], as well as anti-angiogenic effects, likely through upregulating the exosomal levels of some tumor suppressive miRNAs (miR-29b, miR-202 and miR-15a/16), among which miR-29b, an established tumor suppressive miRNA in MM [126–129], accounted for the downregulation of AKT3, PI3K and VEGFA. The gene discussed is AKT3; the disease is neoplasm.