Accordingly, the contact with MM cell lines, as well as MM-derived conditioned media, triggered a marked decrease in lipid accumulation in differentiating murine pre-adipocytes, which displayed gene expression changes in steroid biosynthesis, cell cycle and metabolism (oxidative phosphorylation and glycolysis) and a marked increase of typical MM-supportive genes, including IL-6 and CXCL12. The gene discussed is IL6; the disease is Miyoshi myopathy.