Notably, CD36-depleted effector CD8+ T-cells exhibited increased cytotoxic cytokine production and enhanced tumor killing abilities; conversely, CD36-mediated uptake of FAs by tumor-infiltrating CD8+ T cells induced lipid peroxidation and ferroptosis, and led to reduced production of cytotoxic cytokines and impaired anti-MM activity [153]. The gene discussed is CD8A; the disease is neoplasm.