In addition, in the mutant TDP-43 mouse model of ALS, deleting SARM1 can significantly attenuate motor axon and motor neuron cell body degeneration [38, 39], which indicates that the downregulation of SARM1 could be a result of the body’s compensatory mechanisms to protect neurons from cell death. This evidence concerns the gene SARM1 and amyotrophic lateral sclerosis.