For instance, serum exosomal hsa_circ_0002130 has been found to promote osimertinib-resistance by sponging miR-498 (Ma et al 2020), tumor-derived exosomal circRNA_102481 contributes to EGFR-TKI resistance through the miR-30a-5p/ROR1 axis (Yang et al. 2021c), and exosome-transmitted circVMP1 facilitates cisplatin resistance in non-small cell lung cancer by targeting the miR-524-5p-METTL3/SOX2 axis (Xie et al. 2022). This evidence concerns the gene SOX2 and non-small cell lung carcinoma.