Firstly, one-way COX regression analysis for age, race, gender, tumor primary site, tumor size, TNM stage of the 8th edition of AJCC, serum carcinoembryonic antigen, nerve invasion, lymph node metastasis, liver metastasis, lung metastasis, bone metastasis, and brain metastasis were performed. Here, CEACAM5 is linked to metastatic malignant neoplasm in the lymph nodes.