BLM and cancer: Given the oxidative stress phenotype of cells lacking the Bloom's syndrome helicase BLM (Nicotera et al. 1989, 1993; Poot et al. 1989; Lloret et al. 2008; Subramanian et al. 2021), the human homolog of yeast Sgs1, increased ROS could contribute to both the initiation and progression of cancers in this highly cancer-prone syndrome (German and Ellis 1998), which would be further enhanced by any changes in Sod2 expression levels.