The ATP-dependent RNA helicase Nam7/Upf1, which functions in nonsense-mediated mRNA decay but is also required for telomere length maintenance (Leeds et al. 1992; Lew et al. 1998; Gatbonton et al. 2006), was also significantly upregulated (P < 0.05); its human homolog UPF1 also helps preserve telomere stability and is a potential tumor suppressor (Azzalin et al. 2007; Chen et al. 2021). Here, UPF1 is linked to neoplasm.