AKT1 and cancer: Using the KEGG database, we identified several androgen-regulated pathways that are affected by both AR and HIRA KO (Supplementary Figure S2B and Supplementary Table S2), including cancer- and metastasis-associated pathways, as FoxO (48), TNF (49), TGF-beta (50), PI3K-Akt (48), MAPK (51) and Wnt (52).