Other examples of complex, high-dimensional, and multi-modal Whole Person Modeling designs can be found in the study of Alzheimer’s disease; Singanamalli et al. (2017) [162] used cascaded multi-view canonical correlation analysis to classify stages of Alzheimer’s disease in ADNI [163], integrating cognitive (1 feature), structural MRI (327 features), fluorodeoxyglucose (FDG)-positron emission tomography (PET) (2 features), cerebrospinal fluid (CSF) proteomics (3 features), plasma proteomics (146 features), and APOE genotype data. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.