According to the different CPS scores, tumors can be classified into three PD‐L1 expression‐based subtypes: CPS < 1 is considered no expression, which is equivalent to “cold” tumors; 1 ≤ CPS < 50 is considered low expression, which is equivalent to “variable” tumors; when CPS ≥50, the tumor is considered to be highly expressed, corresponding to a “hot” tumor.75, 76. The gene discussed is CD274; the disease is neoplasm.