Importantly, recent studies have suggested that, in addition to its role in HSC depletion, gain‐of‐function mutant P53 proteins have oncogenic effects on hematopoiesis, which may contribute to clonal hematopoiesis, myeloid leukemia, and other hematological malignancies.60, 61, 62. The gene discussed is TP53; the disease is hematologic disorder.