Similarly, suppression of Myc or Brd4, a Myc transcriptional coactivator, helps attenuate drug cytotoxicity through hindering the initiation of apoptosis by BIM and BID in the DTCs from BC treated with chemotherapy,77 indicating that inhibition of Myc promotes DTC survival by reducing the activity of proapoptotic proteins. The gene discussed is MYC; the disease is breast cancer.