DNA methylation is coregulated by DNA methyltransferases and demethylases, which can modulate drug resistance in tumor cells mainly through regulating apoptosis, stemness, EMT, and cell proliferation through Notch and Wnt/β‐catenin signaling pathways.175, 176, 177, 178, 179, 180, 181. The gene discussed is MBD2; the disease is neoplasm.