ACTA1 and Hepatic fibrosis: As expected, incubation with CAL or NPs/CAL reduced TGF‐β1‐induced overexpression of α‐SMA, which revealed that CAL was able to restore activated HSCs to a resting state, whereas downregulation in α‐SMA expression was more significant after incubation with NPs/CAL, suggesting that NPs/CAL had good anti‐hepatic fibrosis efficacy in vitro.