Moreover, it was found that the histone deacetylase (HDAC) inhibitors such as a selective inhibitor of class II HDAC (MC1568), valproic acid, and sodium butyrate increased the EAAT1 (GLAST)/EAAT2 (GLT-1) expression and the glutamate uptake in both in vitro and in vivo models of ALS and Mn-induced neurotoxicity (Johnson et al., 2018). Here, SLC1A2 is linked to amyotrophic lateral sclerosis.