Among more than 50 genes related to ALS, a variety of genes (SOD1, C9orf72, TDP-43, ubiquilin-2, VCP, etc.)directly affect the pathways of UPS and autophagy system (Nassif et al., 2017; Li et al., 2023). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.