Moreover, TDP-43 has been shown to act as a specific translation enhancer for several mRNAs, including DENN/MADD domain containing 4A (Dennd4a) and calmodulin binding transcription activator 1 (Camta1), which are implicated in the neurodegeneration of ALS. The gene discussed is DENND4A; the disease is amyotrophic lateral sclerosis.