This study also found that IGF-1 treatment inhibited levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 at 4 h after stroke, while only IL-6 and IL-13 continued to be inhibited at 24 h after stroke, as did chemokines GRO-KC and CCL2. This evidence concerns the gene CXCL1 and stroke disorder.