MYRF and brain edema: Reversible splenial lesions with transient reduced diffusion are observed in certain diseases and conditions, including high-altitude cerebral edema, rapid withdrawal of antiseizure medications, Kawasaki disease, X-linked Charcot–Marie–Tooth disease, myelin regulatory factor (MYRF) mutations, and encephalitis/encephalopathy (Starkey et al., 2017), which have been termed reversible splenial lesion syndrome (RESLES) and cytotoxic lesions of the corpus callosum (CLOCCs) (Blaauw and Meiners, 2020).