BDNF and metabolic syndrome: On the contrary, EE has shown beneficial effects on hippocampal neurogenesis, CNS functional connectivity, brain plasticity, synaptogenesis, and BDNF enhancement in animal models, regardless of the practice of physical exercise (Bayat et al., 2015; Narducci et al., 2018; de Souza et al., 2019; Furman et al., 2019), that could counteract cognitive deficits induced by MetS.