EIF2AK2 activity is regulated by interferon-induced double-stranded RNA-dependent protein kinase activator A (PRKRA), and a biallelic variant of PRKRA is a confirmed cause of dystonia (DYT-PRKRA) (DYT-PRKRA) (Camargos et al., 2008; Zech et al., 2014). This evidence concerns the gene EIF2AK2 and Dystonia.