EIF2AK2 and Dystonia: In patient-derived cells carrying the dystonia-causing variant of PRKRA, the affinity of PRKRA-EIF2AK2 interaction is enhanced, and patient fibroblasts exhibit increased and sustained protein kinase R and eIF2α phosphorylation under ER stress (Di Prisco et al., 2014; Trinh et al., 2014; Vaughn et al., 2015; Kuipers et al., 2021).