In contrast to this, a more recent cross-sectional analysis in participants over 50 years of age, with normal cognition or objectively defined subtle cognitive impairment (Obj-SCD), showed that higher NfL levels were associated with lower global cognition, verbal episodic memory, visual episodic memory and executive function (Huang et al., 2022). The gene discussed is NEFL; the disease is Schnyder corneal dystrophy.