In contrast, in a cohort including cognitively unimpaired, MCI and AD dementia participants with a mean age of 72.9 (SD 7.1) years, faster increasing plasma NfL levels correlated with a faster decline in global cognition in participants with MCI and dementia, but not in cognitively unimpaired participants (Mattsson et al., 2019). This evidence concerns the gene NEFL and dementia.